Development of innovative strategies for the preparation and purification of Ketamine
Collin, Diégo
Promotor(s) : Monbaliu, Jean-Christophe ; Leyssens, Tom
Date of defense : 26-Jun-2017 • Permalink : http://hdl.handle.net/2268.2/2473
Details
Title : | Development of innovative strategies for the preparation and purification of Ketamine |
Translated title : | [fr] Développement de nouvelles stratégies pour la synthèse et la purification de la Ketamine |
Author : | Collin, Diégo |
Date of defense : | 26-Jun-2017 |
Advisor(s) : | Monbaliu, Jean-Christophe
Leyssens, Tom |
Committee's member(s) : | Monbaliu, Jean-Christophe
Damblon, Christian Leyssens, Tom Provins, Laurent |
Language : | English |
Number of pages : | 75 |
Keywords : | [en] Ketamine [en] active pharmaceutical ingredient, [en] Innovative strategies [en] flow chemistry [en] purification |
Discipline(s) : | Physical, chemical, mathematical & earth Sciences > Chemistry |
Funders : | Center for Integrated Technology and Organic Synthesis (CiTOS) |
Research unit : | Center for Integrated Technology and Organic Synthesis (CiTOS) |
Name of the research project : | Development of innovative strategies for the preparation and purification of Ketamine |
Target public : | Researchers Professionals of domain Student |
Institution(s) : | Université de Liège, Liège, Belgique |
Degree: | Master en sciences chimiques, à finalité approfondie |
Faculty: | Master thesis of the Faculté des Sciences |
Abstract
[en] Racemic ketamine receives breakthrough therapy designation for major depressive disorder with imminent risk for suicide, from the US Food and Drug Administration. (R,S)-Ketamine was synthesized in 1962 by the American chemist, Calvin Lee Stevens. Until to date, this pharmaceutical product was used as anesthétique in the medicinal field. Racemic ketamine is synthesized according 4 general steps under batch conditions. However, the poor efficiency and flexibility of batch processes is one out of several factors leading to drug shortages reported by the FDA. In this research, we showed the investigation of racemic ketamine synthesis in order to develop innovative strategies for the preparation under continuous-flow process and purification of racemic ketamine by crystallization process.
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